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Conrad Notes IndexspacerAmerican Pain Society Meeting Index

Conrad Notes
a timely medical meeting newsletter
CONTROLLED-RELEASE MORPHINE TABLETS VS CAPSULES

C. R. Brown, MD, Waikato Clinical Research, Hamilton, NZ, reported significantly better analgesia but more adverse events with a single tablet (T) dose compared with the capsule (C) formulation of 60 mg morphine sulfate (MS). Further encapsulation of T and C helped maintain double-blinding in this study on 102 orthopedic surgery patients. MS Contin Tablets and Kapanol Capsules were used in this study.
Patient Enrollment Equal numbers (51 per group) of patients comparable for baseline pain, age (19 to 75 years) and race (86% or 90% white) participated. Gender ratios differed: T = 53% male and C = 71% male.
Pain Relief A 12-hr observation period followed randomized oral administration of T or C. Similar onsets of pain relief, according to categorical and visual analog scales followed. T led to significantly more (p<0.05) pain relief at 1.5, 2, 5, 6 and 7 hours compared with an equal MS dose delivered by C. Additional superiority in mean pain intensity difference occurred at 3 and 4 hours after dosing (p<0.05). Also, average peak and and total pain relief were significantly better in the T group.
Adverse Events Sixty-one per cent of the 51 T-dosed patients and 43% of an equal number of C-dosed patients reported MS-related adverse events. Brown reported somnolence as most common (45% of T patients and 24% of C patients). One patient vomited 12 minutes after C. Another had developed a low oxygen saturation at about 9 hours and pyrexia after T.

Eugene A. Conrad

Presented at American Pain Society Meeting on 15 Nov 1996
CONRAD NOTES, © November 1996 All Rights Reserved
Eugene A. Conrad, PhD, MPH / ISSN 1078 / posted 26-Dec-1996

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